NEJM publishes key Gazyva data in lupus nephritis

7 February 2025

Roche (ROG: SIX) has reported positive results from its Phase III REGENCY trial of Gazyva (obinutuzumab) for the treatment of lupus nephritis, showing a statistically significant improvement in kidney function compared to standard therapy.

The results were published in the New England Journal of Medicine and presented at the 2025 World Congress of Nephrology.

The trial showed that 46.4% of patients who received Gazyva alongside standard therapy (mycophenolate mofetil/glucocorticoids) achieved complete renal response at 76 weeks. This was significantly higher than the 33.1% of patients who achieved the same response with standard therapy alone.

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