Revolution Meds and Summit Therapeutics ink clinical collaboration

1 July 2025

Clinical-stage oncology company Revolution Medicines (Nasdaq: RVMD and fellow USA-based Summit Therapeutics (Nasdaq: SMMT) have entered into a clinical collaboration in multiple solid tumor settings.

They plan to evaluate the safety and efficacy of each of Revolution Medicines’ clinical-stage RAS(ON) inhibitors, including the multi-selective inhibitor daraxonrasib (RMC-6236), G12D-selective inhibitor zoldonrasib (RMC-9805) and G12C-selective inhibitor elironrasib (RMC-6291), in combination with Summit Therapeutics’ ivonescimab, a PD-1 / VEGF bispecific antibody.

Summit’s share closed up 3.3% at $21.28 on the news yesterday, while Revolution was barely changed.

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