Summit and Akeso's ivonescimab shows significant OS benefit

10 November 2025

US oncology company Summit Therapeutics (Nasdaq: SMMT) and its partner Akeso (9926.HK) have communicated results from the Phase III HARMONi-A trial - conducted in China and sponsored by the latter firm - featuring the novel, potential first-in-class investigational bispecific antibody, ivonescimab.

The data was presented as part of the Annual Meeting of the Society for Immunotherapy of Cancer (SITC 2025) in National Harbor, Maryland.

In the study concerned, the use of ivonescimab combined with platinum-doublet chemotherapy was evaluated in patients with epidermal growth factor receptor (EGFR)-mutated, locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) who have progressed after treatment with an EGFR tyrosine kinase inhibitor (TKI) against placebo plus platinum-doublet chemotherapy.

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