Tvardi tanks on disappointing data on fibrosis candidate

14 October 2025

Texas, USA-based fibrosis drug developer Tvardi Therapeutics (Nasdaq: TVRD) shares plunged 84% on Monday to $6.59, erasing much of its previous 128% six-month gain, following disappointing Phase IIa clinical trial results for its TTI-101 drug in idiopathic pulmonary fibrosis (IPF).

The selloff reduced the clinical-stage biotech’s market capitalization to approximately $63 million.

The REVERT IPF Phase II clinical trial was a randomized, double-blind, placebo-controlled clinical trial of TTI-101 alone or in addition to nintedanib (Ofev), a blockbuster drug marketed by Germany’s Boehringer Ingelheim, in patients with IPF.

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