Boehringer’s iclepertin Phase III program in schizophrenia misses goals

17 January 2025

German family-owned pharma major Boehringer Ingelheim today announced top-line results from the Phase III CONNEX clinical program in cognitive impairment in adults with schizophrenia, showing that primary and key secondary endpoints were not met.

Overall, the company noted, no statistically-significant effects on cognition or functioning were observed in patients treated with iclepertin versus placebo at six months. All three trials demonstrated that iclepertin, a glycine transporter 1 (GlyT1) inhibitor, was generally well tolerated, with a safety profile that remains consistent with previous studies.

As a result, Boehringer says it has decided to discontinue the long-term extension trial, CONNEX-X, effective immediately.

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