USA-based Amylin Pharmaceuticals' chairman, Joseph Cook, should resign over the failure of the diabetes drug Byetta (exenatide), according to a letter from billionaire investor Carl Icahn. Mr Icahn accuses the chairman of instigating a "flawed strategy" for the drug and presiding over a period in the company's history that has seen losses in shareholder value. The move follows the resignation of founding board member Howard Greene, who cited similar issues with the firm's strategy. Mr Icahn is calling for a new roster on the board - including former ImClone chairman Alex Denner - maintaining that his candidates would renegotiate the firm's Byetta deal with Eli Lilly to grant Amylin both royalties and a co-promotion option.
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