CellCept falls short in Phase III trial
The USA's Aspreva Pharmaceuticals and Swiss drug major Roche say that the co-developed oral immunosuppressant CellCept (mycophenolate motefil) has failed to demonstrate superiority to intravenous cyclophosphamide in the treatment of patients with lupus nephritis. Specifically, CellCept elicited a similar therapeutic response to the comparator drug (56.2% versus 53%).
The firms said that, based on the results, which related to the induction phase of the study, they are considering their options regarding submission of the drug to regulatory authorities. Aspreva added that it plans to make full data available at a future scientific meeting.
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