CEO among 25% of staff out the door at cash-strapped Prime

20 May 2025

Shares in Prime Medicine (Nasdaq: PRME), a US biotech seeking to develop one-time curative genetic therapies, closed 16% lower Monday.

The US firm earlier announced a strategic restructuring, including the deprioritization of its chronic granulomatous disease (CGD) programs, as well as a cost and workforce reduction to focus on its liver franchise and programs funded through external partnerships.

Prime Medicine is currently advancing in vivo programs to cure two of the largest genetic liver diseases, Wilson’s disease and alpha-1 antitrypsin deficiency (AATD), with initial clinical data from both programs expected in 2027.

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