Compugen's 25017 peptide inhibits angiogenesis model
Compugen says that CGEN-25017, its novel peptide antagonist of the Angiopoietin/Tie-2 pathway, has shown inhibitory effects in a model of angiogenesis.
These initial results support the potential use of this novel peptide for the treatment of angiogenesis-related diseases, such as cancer, macular degeneration, diabetic retinopathy, psoriasis, arthritis and atherosclerosis, the firm noted.
The sequence and potential use of CGEN-25017 was first predicted in silico using Compugen's DAC Blockers Platform, which was designed to predict peptides that block proteins of interest from achieving certain disease-associated conformations.
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