US drug developer CytRx has reported the results of a clinical dosing trial showing its orally-available, dual Bcr-Abl and Lyn-kinase inhibitor INNO-406, demonstrated clinical responses in patients with chronic myeloid leukemia who have the Philadelphia Chromosome (Ph+) and are intolerant of, or resistant to, Gleevec (imatinib) and second-line tyrosine kinase inhibitors such as Sprycel (dasatinib) and Tasigna (nilotinib).
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