Elevated CYP24 expression linked to CKD
US drug developer Cytochroma have reported study data showing increased expression of CYP24 in a preclinical model of chronic kidney disease. These findings suggest that abnormally increased expression of CYP24, the cytochrome P450 enzyme specific for catabolizing vitamin D, may be a key consideration in the management of secondary hyperparathyroidism in CKD.
According to the firm, this highlights the potential benefit of CTA018, the company's novel vitamin D hormone analog designed to simultaneously activate the vitamin D signaling pathway and inhibit CYP24. CTA018 injection which is currently in Phase II trials.
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