ESMO: AstraZeneca and Daiichi Sankyo’s Enhertu achieved a 61.6% PFS

13 September 2024

Among the first presentations at the European Society for Medical Oncology (ESMO) meeting that kicked off today, were results from the DESTINY-Breast12 Phase IIIb/IV trial of Enhertu (trastuzumab deruxtecan).

The data showed that Enhertu demonstrated substantial overall and intracranial clinical activity in a large cohort of patients with HER2-positive metastatic breast cancer who have brain metastases and received no more than two prior lines of therapy in the metastatic setting.

Enhertu is a specifically engineered HER2-directed DXd antibody drug conjugate (ADC) discovered by Japan’s Daiichi Sankyo (TYO: 4568) and being jointly developed and commercialized with UK pharma major AstraZeneca (LSE: AZN).

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