Generic name for novel Hsp90 inhibitor approved
US drug firms Infinity Pharmaceuticals and MedImmune say that the US Adopted Names (USAN) Council, in consultation with the World Health Organization's International Nonproprietary Names Expert Committee, has approved the use of the non-proprietary or generic name retaspimycin for the companies' lead heat shock protein 90 (Hsp90) inhibitor, -504.
Retaspimycin HCl is currently being evaluated in clinical trials for the potential treatment of a variety of solid tumor cancers, including gastrointestinal stromal tumors, non-small cell lung cancer and hormone resistant prostate cancer.
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