UK drug major GlaxoSmithKline has formed a collaboration to develop a drug-antibody dual treatment for amyloidosis with the University College London spinout company Pentraxin Therapeutics.
Under the terms of the agreement, Pentraxin will receive undisclosed, early-stage, success-based and development milestones, as well as royalties.
The partnership will focus on the small-molecule drug CHPHC, which has shown early results, but could not achieve a significant benefit for patients with advanced disease. Pentraxin achieved greater success by combining CPHPC treatment with an antibody that seeks out the amyloid deposits in the organs of mice.
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