Isis Begins Phase I With New HIV Therapy
- Isis Pharmaceuticals has begun Phase I trials with ISIS 5320 forthe treatment of HIV infection. The compound works via a novel mechanism - it is negatively charged and binds to a particular region of the gp120 protein, which prevents virus-to-cell and cell-to-cell transmission, says the company. It has shown in vitro activity against a range of HIV-1 and HIV-2 strains, with no resistance noted as yet.
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