Biotechnology Eli Lilly has announced positive top-line results from the Phase III BRUIN CLL-314 trial of Jaypirca (pirtobrutinib), a non-covalent (reversible) Bruton's tyrosine kinase (BTK) inhibitor, versus Imbruvica (ibrutinib), a covalent BTK inhibitor, in chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). 12 August 2025