Metsera’s obesity candidate ‘comparable to leading GLP-1-based medicines’

10 June 2025

New York-based Metsera (Nasdaq: MTSR), a biopharma developing medicines for obesity and metabolic diseases, closed Monday’s trading nearly 11% higher.

The company earlier announced positive top-line data from the Phase I trial of MET-233i, an ultra long-acting amylin analog engineered for class-leading durability, potency, and combinability with Metsera’s fully-biased monthly GLP-1 receptor agonist candidate, MET-097i.

In the study, MET-233i demonstrated up to 8.4% mean placebo-subtracted weight loss at day 36, a 19-day observed half-life supporting once-monthly dosing, and a favorable tolerability profile with no safety signals.

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