Mixed results for GSK’s Zejula/Jemperli combo

20 December 2024

UK pharma major GSK (LSE: GSK) today released mixed headline results from the FIRST-ENGOT-OV44 Phase III trial evaluating Zejula (niraparib) and Jemperli (dostarlimab) in first line advanced ovarian cancer.

The positive news was that the study met its primary endpoint of progression-free survival (PFS) demonstrating a statistically-significant difference with the addition of dostarlimab to both standard of care carboplatin-paclitaxel chemotherapy and niraparib maintenance, with or without bevacizumab, Roche’s Avastin.

However, GSK noted that the key secondary endpoint of overall survival (OS) did not meet statistical significance. Further analyses are ongoing and data will be shared with health authorities and presented at an upcoming scientific meeting, the company said.

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