Neose Technologies has received a milestone payment from Danish diabetes giant Novo Nordisk under their November 2003 license agreement for the use of the US firm's GlycoPEGylation technology to develop a next-generation version of Factor IX. The agent is used in the treatment of hemophilia B, which is caused by a deficiency of this blood plasma protein that affects the clotting property of blood. The company is also working with Novo Nordisk under separate license deals to develop GlycoPEGylated versions of recombinant Factors VIIa and VIII. A Phase I trial of GlycoPEG-Factor VIIa is currently ongoing.
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