New Phase III results for Aphton's G17DT

10 November 2003

The USA's Aphton Corp has released positive results from a Phase IIItrial of its anti-gastrin immunogen G17DT in patients with pancreatic cancer.

The randomized, double-blind, placebo-controlled, multicenter European study involved 154 treatment-naive patients with advanced pancreatic cancer. The primary objective of the trial was to compare overall survival between the G17DT group and the placebo arm. Secondary measures included a comparison of quality of life, time-to-deterioration of Karnofsky score (a subjective measure of well-being) and changes in dry weight.

The findings from the intent-to-treat population included:

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