NICE recommends NHS use of Opdivo and Yervoy combo for mCRC

22 April 2025

UK health technology assessor the National Institute for Health and Care Excellence (NICE) has issued Final Draft Guidance (FDG) recommending the reimbursement of Opdivo (nivolumab) in combination with Yervoy (ipilimumab).

Developed by US pharma major Bristol Myers Squibb (NYSE: BMY), the combination is backed for the first line treatment of adult patients with mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) unresectable or metastatic colorectal cancer (mCRC).

The NICE recommendation follows a Medicines and Healthcare products Regulatory Agency (MHRA) indication extension of nivolumab-ipilimumab on April 4, 2025.

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