Novo Nordisk jumps on positive early trial with SC amycretin for obesity

24 January 2025

Denmark’s Novo Nordisk (NOV: N) saw its shares rise as much as 13% to 659.20 kroner this morning, after it announced top-line results from a Phase Ib/IIa clinical trial with amycretin once weekly subcutaneous (SC) administration.

Amycretin is both an amylin and GLP-1 receptor agonist and a once-daily oral option, unlike the firm’s blockbuster obesity drug Wegovy (semaglutide), which is an injectable medication, as is Eli Lilly’s (NYSE: LLY) chief rival the GLP-1 receptor agonist tirzepatide, trade named Mounjaro and Zepbound, as well as the other leading weight loss drugs on the market.

Analysts at Bank of America said the results showed amycretin could be “best in class,” delivering as much as 25% weight loss. But the drug still needs to go through a large late-stage trial, so would not be on the market until at least 2028, they said.

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