Novo Nordisk keeps nose ahead of Lilly with oral GLP-1 filing

23 April 2025

Shares in Eli Lilly (NYSE: LLY) shot up last Thursday after the US pharma major announced positive top-line Phase III results from ACHIEVE-1, comparing orforglipron to placebo in adults with type 2 diabetes and inadequate glycemic control with diet and exercise alone.

The impressive data confirmed orforglipron as a frontrunner in the race to introduce the first oral glucagon-like peptide-1 (GLP-1) receptor agonist to the market, with its potential as a convenient once-daily pill for obesity making it a lucrative prospect, in particular.

But Lilly has a rival in the race, that being Novo Nordisk (NOV: N), and the Danish drugmaker is in fact currently in pole position, having already submitted an application to the US Food and Drug Administration (FDA) seeking approval of an oral version of its GLP-1 receptor agonist Wegovy (semaglutide).

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