Ph II study of ImClone's IMC-A12 starts enrolling patients
US drugmaker ImClone Systems has started enrolling patients into its disease-directed randomized Phase II trial of IMC-A12 in patients with previously-treated HER2-expressing locally-advanced or metastatic breast cancer. The primary objective of this study is to evaluate the antitumor activity of the combination of capecitabine and lapatinib with and without IMC-A12 in patients with HER2-expressing Stages IIIB, IIIC, or IV breast cancer that has progressed on trastuzumab-containing treatment. This study is being conducted by the US North Central Cancer Treatment Group.
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