Canada-based AEterna Zentaris (TSX: AEZ) has highlighted an article published in the May 2012 issue of Plos One, which outlines a novel mechanism of action of the company's oral anti-cancer compound, perifosine, which could provide a rationale for a novel approach to the treatment of malignant pleural mesothelioma (MMe), an aggressive type of cancer associated with exposure to asbestos.
Perifosine's activity was tested on human mesothelial cells and different mesothelioma cell lines, in order to provide evidence of its efficacy as single agent and combined therapy.
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