Astellas' once-daily Advagraf demonstrates superiority to twice-daily immediate release
Japanese drug major Astellas (TYO: 4503) has published results of a study demonstrating that early and sustained use of Advagraf (tacrolimus) offers a significant graft survival benefit in liver transplant patients over the current standard of care.
Formulated as a once-daily immunosuppressant, the drug demonstrated superiority to the twice-daily immediate-release formulation. Graft survival benefit was 8% in patients on Advagraf versus tracrolimus immediate release. The study was conducted at the European Liver Transplant Registry, which holds data for 98% of liver transplants conducted in Europe.
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