
Boston-based Dana-Farber Cancer Institute and Japanese drug major Astellas Pharma (TYO: 4503) have entered into a three-year R&D collaboration for small molecule inhibitors of oncogenic K-Ras for the treatment of cancer.
K-Ras is the most commonly mutated oncogene in human cancers, with about 30% of all cancers harboring activating rasmutations. The cancers with this type of mutation are difficult to treat and clinical outcomes are poor even with aggressive medical interventions. No effective therapy currently exists.
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