Definium reports third positive Phase III readout for LSD anxiety drug

14 September 2026

New York-based Definium Therapeutics (Nasdaq: DFTX) has reported positive topline results from Panorama, its second Phase III trial of DT120 ODT (lysergide) in generalized anxiety disorder (GAD).

The 245-patient study met its primary endpoint, with participants receiving DT120 ODT 100 µg showing a placebo-adjusted reduction of 5.1 points on the Hamilton Anxiety Rating Scale (HAM-A) at week 12, a moderate effect size.

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