Eisai reports positive Ph III results for perampanel in partial epilepsy
Japan's fourth largest drugmaker Eisai (TYO: 4523) has announced encouraging results of a Phase III study for the investigational compound perampanel (E2007), a first-in-class, highly selective non-competitive AMPA-type glutamate receptor antagonist, discovered by Eisai and under development for adjunctive treatment of partial seizures in patients with epilepsy.
The double-blind, placebo-controlled, parallel-group study (Study 306) showed that perampanel was well-tolerated and effective in reducing median seizure frequency and increasing responder rates versus placebo, the primary outcome measures in the USA and the European Union, respectively. The findings were statistically significant in 4mg and 8mg doses compared to placebo. A linear trend for dose response was also statistically significant.
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