GSK ends synthetic lethality pact with Ideaya

9 December 2025

GSK (LSE: GSK) has chosen to unwind its synthetic lethality alliance with US biotech Ideaya Biosciences (Nasdaq: IDYA), triggering a 90-day transition period in which rights to two oncology programs, IDE275 and IDE705, will return to Ideaya.

The decision was disclosed in an SEC filing, which stated that Ideaya will weigh next steps for both assets in 2026 and that its projected cash runway remains intact through 2030.

The termination brings a full close to a five-year relationship that originally aimed to advance targeted treatments for solid tumors. The companies did not disclose why GSK opted to step back from the collaboration.

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