Karyopharm crashes as Phase III XPORT-EC-042 trial misses goal

31 July 2026

US cancer focused pharma Karyopharm Therapeutics (Nasdaq: KPTI) shares plunged 68.47% to $7.01 in Thursday’s after-hours trading, after the company reported results from its Phase III trial which failed meet its primary goal.

The company announced top-line results from its Phase III XPORT-EC-042 trial evaluating selinexor as a maintenance-only therapy compared to placebo in adult patients with TP53 wild-type advanced or recurrent endometrial cancer.

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