Lilly cuts Zepbound vial prices as obesity drug competition heats up

2 December 2025

US pharma major Eli Lilly (NYSE: LLY) has lowered the price of Zepbound (tirzepatide) single-dose vials on its Lilly Direct platform, widening access in a fast-moving obesity market. The 2.5-mg starting dose now matches the $299 monthly price set for the multi-dose pen awaiting US approval.

The 5-mg vial will cost $399 per month and higher doses $449 via the company’s Self Pay Journey Program. Regular prices outside the program range from $599 to $1,049. The update follows Lilly’s recent most-favored nation pricing deal with the Trump administration for Zepbound, Mounjaro (tirzepatide) and orforglipron.

“Far too many people who need obesity treatments still face cost and coverage barriers,” said Ilya Yuffa, president, Lilly USA and Global Customer Capabilities. He added that the company will continue expanding delivery options to support access for more patients.

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