Mixed Ph III data for Pfizer's tofacitinib vs Enbrel in plaque psoriasis
US pharma giant Pfizer (NYSE:PFE) has announced detailed results from OPT Compare (A3921080), a Phase III study of tofacitinib (trade name Xeljanz), the first in a new class of treatment, oral Janus kinase (JAK) inhibitors, the safety and efficacy of which are being investigated for the treatment of adults with moderate-to-severe chronic plaque psoriasis.
Top-line results from OPT Compare were previously announced in October 2013. This is the first of five studies from the Phase III Oral treatment Psoriasis Trial (OPT) Program, one of the largest global clinical trial programs in moderate-to-severe chronic plaque psoriasis to date, Pfizer noted.
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