Novartis' Zometa fails to meet Ph III primary endpoint in early breast cancer, stalling this indication; but Afinitor looks good
Results from the second interim analysis of the Phase III AZURE (Adjuvant Zoledronic acid to redUce REcurrence) trial show that Swiss drug major Novartis; (NOVN: VX) Zometa (zoledronic acid) - which has been viewed as one of the most promising drugs in breast cancer and also is sold for the treatment of osteoporosis as Reclast - failed to demonstrate a disease-free survival (DFS) advantage when added to standard adjuvant (post-surgery) chemotherapy and/or hormonal therapy in pre- and post-menopausal women with early breast cancer.
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