Onyx Pharma expands Ph III carfilzomib study ahead of EMA filing
USA-based Onyx Pharmaceuticals (Nasdaq: ONXX) says it plans to expand the Phase III European clinical trial FOCUS, which is evaluating the efficacy and tolerability of carfilzomib, a selective next-generation proteasome inhibitor. The FOCUS trial is designed to support the registrational filing with the European Medicines Agency (EMA) in patients with relapsed and refractory myeloma.
Onyx acquired the drug along with its $851 million acquisition of US firm Proteolix (The Pharma Letter October 12, 2009). Onyx subsequently licensed Japanese rights to carfilzomib, as well as ONX 0912, to Ono Pharma for a total consideration of nearly $340 million (TPL September 9, 2010).
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