Pfizer and Janssen's bapineuzumab fails to meet one Ph III study endpoints for Alzheimer's

24 July 2012

US drugs behemoth Pfizer (NYSE: PFE) revealed yesterday that the co-primary clinical endpoints, change in cognitive and functional performance compared to placebo, were not met in the first of four Phase III studies of bapineuzumab conducted by partner Janssen, part of health care giant Johnson & Johnson (NYSE: JNJ), in patients with mild-to-moderate Alzheimer’s disease who carry the ApoE4 (apolipoprotein E epsilon 4) genotype (Study 302). Pfizer’s shares fell 1.5% to $23.25 in after-hours activity, while those of J&J dipped 0.4% in after-hours trading.

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