Phase IIb data suggest promise for ReVision's oral fenretinide in treating dry AMD

19 October 2010

Privately-held US ophthalmic drug developer ReVision Therapeutics yesterday announced results from a Phase IIb trial suggesting that fenretinide (RT-101) slows lesion growth and preserves visual acuity in patients with geographic atrophy (GA), the most advanced form of dry age-related macular degeneration (AMD).

The data, presented at annual meeting of the American Academy of Ophthalmology in Chicago, showed that a sustained reduction in retinol binding protein (RBP) levels of 60% to 75% was predictive of positive treatment response to fenretinide. Patients receiving the drug who achieved this RBP reduction threshold experienced a around 49% slower rate of lesion growth compared to patients receiving placebo.

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