Positive Phase II data on Sparrow Pharma’s clofutriben in diabetes
Boston, USA-based cardiometabolic specialist Sparrow Pharmaceuticals announced positive Phase II clinical data for clofutriben, its lead investigational 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor, in adults with type 2 diabetes (T2D) at the 2026 Annual American Diabetes Association (ADA) Scientific Session.
In the intent-to-treat (ITT) population, clofutriben produced statistically-significant improvements in HbA1c and total cholesterol. In a subset of patients with clinical features associated with a greater risk of having elevated cortisol, including inadequately controlled HbA1c despite treatment with two or more antidiabetic medications (EC-risk factor enriched), numerically larger improvements were observed across all cardiometabolic parameters, including HbA1c, glucose, total cholesterol, triglycerides, weight, and blood pressure.
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