Positive results from COMBI-v study of Mekinist and Tafinlar
Results published in the New England Journal of Medicine show that treatment with the combination of trametinib (Mekinist) and dabrafenib (Tafinlar) significantly improved overall survival (OS) compared to vemurafenib monotherapy in previously untreated patients with BRAF V600E/K mutation-positive metastatic melanoma, without increased overall toxicity.
The US Food and Drug Administration approved UK pharma major GlaxoSmithKline’s (LSE: GSK) combination of Mekinist for use in combination with Tafinlar early this year for the treatment of patients with unresectable melanoma or metastatic melanoma with BRAF V600E or V600K mutations (The Pharma Letter January 9).
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