PsiThera raises $47.5 million series A and appoints new CEO

11 December 2025

PsiThera has closed a $47.5 million series A round to advance oral therapies for immune and inflammatory diseases. The company also named former Seres Therapeutics (Nasdaq: MCRB) chief executive Eric Shaff as chief executive.

The financing was led by Samsara Biocapital and Lightstone Ventures, with backing from Roivant (Nasdaq: ROIV), YK Bioventures and Eurofarma Ventures.

“PsiThera has integrated predictive computational power, biophysics, mechanistic biology, and drug hunter expertise into a continuous feedback loop,” said Mr Shaff. He added: “The four-month advancement of our lead program from identification of a novel chemical scaffold hit to lead optimization illustrates how efficiently our discovery engine operates.”

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