Roche hails giredestrant effect in ER-positive early-stage breast cancer

11 December 2025

Swiss pharma giant Roche (SIX: ROG) has announced positive data from the Phase III lidERA Breast Cancer study of giredestrant as an adjuvant endocrine treatment for people with oestrogen receptor (ER)-positive, human epidermal growth factor receptor 2-negative, early-stage breast cancer.

At the pre-specified interim analysis, adjuvant giredestrant significantly reduced the risk of invasive disease recurrence or death by 30% compared with standard-of-care endocrine therapy.

The lidERA results are being presented at the 2025 San Antonio Breast Cancer Symposium and are included in the official press program.

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