Second Phase III success for COMP360 psilocybin sends Compass 38% higher

17 February 2026

Compass Pathways (Nasdaq: CMPS) has announced the successful achievement of the primary endpoint in the ongoing Phase III COMP006 trial, the second of two Phase III studies of COMP360, a synthetic, proprietary formulation of psilocybin, for treatment-resistant depression (TRD).

Psilocybin is a psychedelic compound and is used recreationally under the street name ‘magic mushrooms’, though it is now being trialled as a potential treatment for various mental health conditions.

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