Siegfried and Lonza lead four-way CDMO race in outsourced HPAPI

24 July 2026

Known for their low-dose therapeutic efficacy and high target affinity, high-potency active pharmaceutical ingredients (HPAPIs) are in high demand by biopharma companies, which often outsource their production.

Approximately 41% of innovator and biosimilar HPAPIs come from contract development and manufacturing organizations (CDMOs). With strategic acquisitions and expansions of HPAPI facilities reshaping the HPAPI outsourcing market, four CDMOs – Lonza (LONN: SIX), Siegfried, Aspen, and Veranova - are competing for leadership, with two of them, Lonza and Siegfried, pulling out in front, according to pharma intelligence firm GlobalData.

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