Study confirms everolimus can overcome trastuzumab resistance in HER-2 positive early breast cancer
A study that aimed to understand how the cancer drug everolimus helps overcome the resistance breast cancers can develop to trastuzumab, the active ingredient of Swiss drug major Roche’s (ROG: SIX) Herceptin, has left researchers contemplating a puzzle.
The study showed a statistically non-significant benefit in clinical response rates for some patients with early breast cancer when everolimus, Novartis’ (NOVN: VX) Afinitor, was added to treatment with trastuzumab. Yet the results suggest this benefit is achieved independently of the molecular pathways researchers expected would be involved.
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