Switching to Merck’s DOR/ISL in HIV had 'minimal impact on weight and body composition

15 October 2025

Merck & Co (NYSE: MRK) has presented additional data from Phase III studies of the investigational, once-daily, oral, two-drug regimen of doravirine/islatravir (DOR/ISL) in adults with HIV-1 infection that was virologically suppressed on bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) in trial MK-8591A-052 or antiretroviral therapy [baseline antiretroviral therapy (bART)] in trial MK-8591A-051.

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