Synairgen and Pharmaxis enter research collaboration on LOXL2 inhibitor

5 August 2015
pharmaxis

Respiratory drug discovery and development specialist Synairgen (LSE: SNG) and Australian pharma company Pharmaxis (ASX: PXS) have entered into a research collaboration to develop a selective inhibitor to the lysyl oxidase type 2 enzyme (LOXL2).

This would treat the fatal lung disease idiopathic pulmonary fibrosis, which affects around 100,000 people in the USA. LOXL2 is being targeted because it is known to promote scar tissue which hardens and irreparably damages the lungs of idiopathic pulmonary fibrosis patients. It is hoped that being able to inhibit LOXL2 will slow the buildup of scar tissue and improve survival rates that are worse than for many cancers.

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