Trial miss for AstraZeneca’s SERENA-4 Phase III trial of Etcamah
The SERENA-4 Phase III trial of AstraZeneca’s (LSE: AZN) Etcamah (camizestrant) in combination with palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor, did not meet the primary endpoint of progression-free survival (PFS).
However, the UK pharma major noted, a numerical improvement was observed in the upfront 1st-line treatment of patients with estrogen receptor (ER)-positive, HER2-negative advanced breast cancer who have not received any systemic treatment for advanced disease. The trial evaluated the Etcamah combination versus treatment with an aromatase inhibitor (anastrozole) in combination with palbociclib. The company’s shares were hardly moved following the announcement on Friday.
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