Vandria advances positive Phase I data and eyes 2026 series B
Swiss biotech Vandria has unveiled encouraging first-in-human data for VNA-318, an oral small molecule designed to restore mitochondrial function and cut inflammation in Alzheimer’s disease. The readout, presented at the CTAD meeting in San Diego, supports plans for a Phase II proof-of-concept trial.
The Phase I study enrolled 92 healthy men and assessed single and multiple ascending doses. Vandria reported excellent safety, with no severe or serious adverse events and no discontinuations.
A single dose produced a statistically significant and dose-dependent change in a plasma biomarker of target engagement, alongside pharmacokinetics supportive of once-daily use.
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