Verastem expands ambitions with strong pancreatic cancer data at ASCO

23 May 2025

Verastem Oncology (Nasdaq: VSTM) has unveiled updated early-stage data from its RAMP 205 trial in metastatic pancreatic cancer, bolstering its efforts to broaden use of its dual-drug regimen, Avmapki Fakzynja Co-Pack, beyond its recently approved indication in a rare form of ovarian cancer.

The combination of Avmapki (avutometinib) and Fakzynja (defactinib) with gemcitabine and Nab-paclitaxel yielded an overall response rate of 83% among patients in the cohort selected as the recommended Phase II dose.

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