Zepzelca fails Phase III test in relapsed small-cell lung cancer

15 June 2026

Ireland-headquartered biopharma Jazz Pharmaceuticals (Nasdaq: JAZZ) and Spanish drugmaker PharmaMar (BME: PHM) have reported a late-stage setback for Zepzelca (lurbinectedin) in relapsed metastatic small-cell lung cancer, after the drug missed the main goal of a confirmatory Phase III study.

The LAGOON trial tested Zepzelca alone or in combination with irinotecan against investigators’ choice of topotecan or irinotecan in patients receiving second-line treatment. Neither Zepzelca arm delivered a statistically significant overall survival benefit versus control.

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